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Diabetic Hypoglycemia - an independent electronic journal dedicated to the advancement of hypoglycemia research and clinical management
Diabetic Hypoglycemia Volume 2, Issue 1, May 2009

Clinical Case Study

Rebound hypoglycemia associated with glibenclamide

Professor Ian W Campbell

Diabetic Hypoglycemia May 2009, Volume 2, Issue 1: page 14-15


This issue's case study discusses an elderly man with type 2 diabetes who was undergoing treatment with the long-acting sulfonylurea, glibenclamide. He presented at a hospital emergency department in a comatose state, having suffered from headaches with increasing periods of confusion over the previous 2-3 months. The patient was found to have recurrent sulfonylurea-induced hypoglycemia (SIH). This can be a side-effect of long-acting sulfonylurea treatment in elderly subjects living alone, who have inadequate diet and poor food intake. The patient’s glibenclamide regimen was replaced with a low-dose, short-acting sulfonylurea, and no further hypoglycemic episodes occurred.

Keywords: hypoglycemia, sulfonylurea, type 2 diabetes