Editorial

Impaired hypoglycemia awareness

Simon Heller, BA MB BChir DM FRCP, of the Editorial Board

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 1-2

This editorial by Professor Heller highlights the key points in this issue's Feature Article, describing the mechanisms likely to be involved in the pathophysiological response to hypoglycemia. He also discusses the challenges in developing treatments to prevent defective responses to hypoglycemia.

Feature Article

Impaired counter-regulatory and symptomatic responses to hypoglycemia in type 1 diabetes: underlying mechanisms

Rory J McCrimmon, MD

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 3-7

Dr Rory McCrimmon discusses the defects which develop in individuals with diabetes, leading to diminished awareness of hypoglycemic symptoms and an impaired ability to mount a counter-regulatory response to hypoglycemia. He reviews research in animal models that sheds light on the mechanisms and pathways involved in glucose sensing and the pathophysiological response to hypoglycemia.

Clinical Case Study

Hypoglycemic hemiparesis in a woman with type 1 diabetes: evidence of underlying cerebrovascular disease

Anna R Dover, PhD & Siobhan McLaughlin, PhD

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 8-9

A 53 year old woman with a history of type 1 diabetes and impaired hypoglycemia awareness presented with recurrent left-sided hemiparesis on waking, associated with capillary blood glucose levels of 3.1, 3.9 and 3.2 mmol/l.

In Profile

In Profile - Daniel J Cox, PhD

Nicole Meinel of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 10-11

In this issue of Diabetic Hypoglycemia, we interview Professor Daniel Cox, Professor of Psychiatry and Neurobehavioral Sciences and Internal Medicine, and Director of the Center for Behavioral Medicine Research at the University of Virginia Health Sciences Center.

Diabetes Treatment Review

The economic and patient-centered burden of diabetic hypoglycemia

Nicole Meinel of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 12-14

This Treatment Review examines some of the findings of a recent review on the economic and patient-centered burden of hypoglycemia in patients with type 2 diabetes treated with insulins and/or anti-diabetes drugs, and how the economic burden of hypoglycemia events compares with that in patients with type 1 diabetes.

News Article

News Article - impaired hypoglycemia awareness, hypoglycemia-induced brain damage, and fear of hypoglycemia

Nicole Meinel of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 15-18

In this issue’s News Article, the latest research on impaired hypoglycemia awareness, hypoglycemia-induced brain damage, and fear of hypoglycemia is discussed.

Webwatch

Webwatch - the diabetes pages of the World Health Organization website

Nicole Meinel of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia June 2011, Volume 4, Issue 1: page 19

In each issue of Diabetic Hypoglycemia, we review a website that contains information on diabetes. In this issue, we review the diabetes pages of the World Health Organization (WHO) website (http://www.who.int/diabetes/en/).