Editorial

The ACCORD and ADVANCE trials – could hypoglycemia have contributed to the differences seen in cardiac mortality?

Professor Simon Heller and Dr Rory McCrimmon of the Editorial Board

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 1

This editorial was authored by Professor Simon Heller, one of the ADVANCE investigators, and Dr Rory McCrimmon, and examines the reasons for the observed differences in cardiac mortality between the ACCORD and ADVANCE trials.

Feature Article

Sudden death and hypoglycemia

Simon Heller, BA, MB BChir, DM, FRCP

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 2-7

This feature article provides a detailed examination of the phenomenon of sudden death and hypoglycemia. There is considerable evidence implicating hypoglycemia as a cause of sudden death in both type 1 and type 2 diabetes. Hypoglycemia may also increase the risk of ischemia and sudden death, although it is unclear whether the same mechanisms operating in type 1 diabetes are responsible – a hypothesis which requires considerable further research.

Congress Reporter

Congress Reporter - effects of hypoglycemia on the brain, potential counterregulatory pathways in hypoglycemia, and hypoglycemia prediction techniques

Martin Gilmour of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 8-10

This issue of Diabetic Hypoglycemia reviews several abstracts presented at the 68th Annual Scientific Sessions of the American Diabetes Association (ADA). This review covers the following topics: the effects of hypoglycemia on the brain, new evidence detailing the potential counterregulatory pathways involved in hypoglycemia, and a review of two different hypoglycemia prediction techniques.

Research Round Up

Research Round Up - hypoglycemia and genetics, the brain, and the cardiovascular system

Martin Gilmour of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 11-12

This issue’s research round up focuses on new research in the topics of hypoglycemia and genetics, hypoglycemia and the brain, and hypoglycemia and the cardiovascular system.

Clinical Case Study

Impaired awareness of hypoglycemia

Dr Rohana J Wright, Specialty Registrar, Endocrinology and Diabetes, Cumberland Infirmary, Carlisle, UK

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 13-14

This issue's Clinical case study covers a 22 year old patient with a long history of type 1 diabetes, and impaired awareness of hypoglycemia. The case study also features an editorial comment by Professor Brian Frier.

In Profile

Professor Philip E. Cryer

Martin Gilmour of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 15-16

The second in our series of ‘In Profile’ interviews with influential figures in the field of hypoglycemia features a world-renowned expert in hypoglycemia; Professor Philip E. Cryer, the Irene E. and Michael M. Karl Professor of Endocrinology and Metabolism in Medicine at Washington University in St. Louis.

Diabetes Treatment Review

Insulin pump therapy

Martin Gilmour of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 17-18

Insulin pump therapy (continuous subcutaneous insulin infusion [CSII]) is now an established treatment, allowing patients to manage their diabetes intensively and optimise glycemic control. This issue's treatment review focuses on recent publications looking at the use of insulin pump therapy in diabetes.

Webwatch

Wikipedia's diabetic hypoglycemia page (http://en.wikipedia.org/wiki/Diabetic_hypoglycemia)

Martin Gilmour of the Diabetic Hypoglycemia Editorial Team

Diabetic Hypoglycemia September 2008, Volume 1, Issue 2: page 19

In each issue of Diabetic Hypoglycemia, we review a website that contains information on hypoglycemia. This month we review Wikipedia's diabetic hypoglycemia page (http://en.wikipedia.org/wiki/Diabetic_hypoglycemia).